Studies on the effect of probenecid (benemid) in gout.
نویسنده
چکیده
منابع مشابه
New Uricosuric Agent in the Treatment of Gout
Several uricosuric drugs are now available for the long-term management of gout, the principal being aspirin, probenecid (Benemid), and sulphinpyrazone (Anturan). Recently two further drugs, Zoxazolamine (Flexin) and p-carboxybenzenesulpha-diethylamide (Urelim), have been introduced. Reed, Feichtmeier, and Willett (1958) commented on the uricosuric properties of Zoxazolamine, and drew attention...
متن کاملNew Uricosuric Agent in the Treatment of Gout: para-Carboxybenzenesulpha-diethylamide (Urelim).
Several uricosuric drugs are now available for the long-term management of gout, the principal being aspirin, probenecid (Benemid), and sulphinpyrazone (Anturan). Recently two further drugs, Zoxazolamine (Flexin) and p-carboxybenzenesulpha-diethylamide (Urelim), have been introduced. Reed, Feichtmeier, and Willett (1958) commented on the uricosuric properties of Zoxazolamine, and drew attention...
متن کاملUricosuric agents in the treatment of gout.
Kersley, Cook, and Tovey (1958) reported the therapeutic value of G.28 315 (sulphinpyrazone), a phenylbutazone derivative now known as Anturan (Geigy), in a group of fifteen patients with gout in a clinical trial lasting 3 to 8 months. Benemid and Longacid (Urelim), a benemid-like drug (Ward, Blenkinsop and Co.), were also given in selected cases. The results, as shown by estimations of the uri...
متن کاملMechanism and treatment of hypertriglyceridaemia in gout.
Using the Intralipid lipid tolerance test we could not demonstrate any direct effect of serum triglyceride on uric acid or any influence of hyperuricaemia on triglyceride removal. This result supports previous studies suggesting that hyperuricaemia and hypertriglyceridaemia are linked through the association of obesity and alcohol excess rather than a direct cause and effect mechanism. It was p...
متن کاملAnti-hypertensive effects of probenecid via inhibition of the α-adrenergic receptor.
Probenecid has long been used in the treatment of gout. Its anti-gout mechanisms consist of uric acid reuptake inhibition and the consequent facilitation of uric acid excretion. In the present study, we investigated whether probenecid could exert an anti-hypertensive effect in spontaneously hypertensive rats (SHR). The noninvasive indirect tail cuff method was employed to measure blood pressure...
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ورودعنوان ژورنال:
- Annals of the rheumatic diseases
دوره 13 2 شماره
صفحات -
تاریخ انتشار 1954